Rabbits with incubating experimental syphilis were cured or inadequately treated with penicillin G and some cured rabbits were later reinfected. MHA-TP conversion occurred within 45 days in untreated rabbits. Titres reached peak levels about four months after inoculation and remained relatively high for up to two years.
Differentiation requires a careful history and examination. In some texts the THPA is referred to as the microhaemagglutination assay for antibodies to Treponema pallidum. Get help. GPnotebook no longer supports Internet Explorer. To ensure the site functions as intended, please upgrade your browser. You may feel nothing at all from the needle or lancet, or you may feel a quick sting or pinch. When blood is taken from a vein, an elastic band is wrapped around your upper arm and may feel tight.
You may feel some discomfort when fluid is collected from an open sore. But syphilis sores usually are not very tender or painful. You may feel some discomfort during a lumbar puncture to collect spinal fluid.
There is very little chance of a problem from having a blood sample taken from your fingertip or a vein. There is very little risk of problems from having a sample taken from an open sore, skin rash, or mucous membrane. There is little risk linked with having a lumbar puncture to obtain a spinal fluid sample. Syphilis tests tell if a person has the disease. A reactive or positive test result does not always mean that you have syphilis. Other conditions can cause positive test results.
These include injecting illegal drugs, recent vaccinations, endocarditis, and autoimmune diseases. The accuracy of testing often depends on the stage of syphilis. Testing may need to be repeated if:. Kiley MD - Obstetrics and Gynecology. Author: Healthwise Staff. This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information.
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Updated visitor guidelines. You are here Home » Syphilis Tests. Top of the page. Test Overview Syphilis tests tell if a person has this disease. Testing is done on blood, body fluid, or tissue samples. The VDRL test checks blood or spinal fluid for an antibody that can be produced in people who have syphilis.
This antibody is not produced as a reaction to syphilis specifically, so the test result could be "abnormal" for reasons other than syphilis. Rapid plasma reagin RPR test. The RPR test also finds syphilis antibodies. Rapid immunochromatographic test. This test checks for antibodies that are specific to syphilis. Unlike other tests, the blood sample is not sent to a laboratory. You can find out the results at your doctor visit. Tests to confirm syphilis Tests used to confirm a syphilis infection include: Enzyme immunoassay EIA test.
This blood test checks for syphilis antibodies. This test also checks for antibodies. It can be used to find syphilis except during the first 3 to 4 weeks after exposure. The test can be done on a sample of blood or spinal fluid. Treponema pallidum particle agglutination assay TPPA. It is used after another method tests positive for syphilis. This test is not done on spinal fluid.
Darkfield microscopy. This test uses a special microscope to look for the syphilis germ in a sample of fluid or tissue from an open sore. This test is used mainly to diagnose syphilis in an early stage. The MHA-TP is used to confirm a syphilis infection after another test shows positive results for syphilis. Why It Is Done A syphilis infection can spread through the bloodstream to all parts of the body. A test for syphilis is done to: Screen for syphilis or check how well treatment is working.
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